Enzymology in drug discovery [electronic resource] : part 1 of 2 / Robert A. Copeland.

By: Material type: FilmFilmPublisher number: 3431 | Henry Stewart TalksSeries: Henry Stewart talks. Biomedical & life sciences collection. Small molecule drug discovery.Publication details: London : Henry Stewart Talks, 2013.Description: 1 online resource (1 streaming video file (42 min.) : color, sound)Other title:
  • Enzymology in drug discovery, part 1 of 2
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Contents:
Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.
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Animated audio-visual presentation with synchronized narration.

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Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.

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