Maini, R. N. <br/><br/>
From bench to bedside  evolution of anti-TNFα therapy in rheumatoid arthritis /  [electronic resource] : 
Ravinder Maini. 
 - London :  Henry Stewart Talks,  2009. 
 - 1 online resource (1 streaming video file (59 min.) :  color, sound). 
 - Innate immunity : host recognition and response in health and disease,  2056-452X .
 - Henry Stewart talks.  Biomedical & life sciences collection.  Innate immunity : host recognition and response in health and disease. .
<br/><br/> Animated audio-visual presentation with synchronized narration.  Title from title frames. 
<br/><br/>Contents: What are cytokines? -- Early experiments -- Human cytokines in the 1980s -- Identification of TNFalfa at protein and genomic level -- TNFalfa and anti- TNFalfa antibodies -- Rheumatoid arthritis (RA): burden of disease -- Pathology of RA -- IL-1 and TNFalfa -- Cytokine cascade in RA -- A molecular hypothesis -- First anti-TNF (cA2/infliximab) in clinical trials in RA -- How does anti-TNF work? -- Why is cellularity reduced? -- Anti-TNF therapy inhibits cartilage and especially bone destruction -- Infliximab regulates altered T and B cell immunity -- Biological effects of Infliximab -- Anti-TNF biologicals in the lab -- Efficacy in randomized clinical trials -- Effective anti-TNF therapy demonstrates shared TNF-pathways in other diseases -- Adverse events and safety issues -- Limitations of anti-TNF therapy -- After TNF: what are we looking for? 
<br/><br/> Access restricted to subscribers. 
<br/><br/><br/>Mode of access: World Wide Web. 
<br/><br/><label>Publisher. No.: </label>2179  Henry Stewart Talks 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Arthritis, Rheumatoid--drug therapy.<br/>Immunity, Innate.<br/>Tumor Necrosis Factor-alpha.