TY  - ADVS
AU  - Maini,R.N.
TI  - From bench to bedside: evolution of anti-TNFα therapy in rheumatoid arthritis 
T2  - Innate immunity : host recognition and response in health and disease,
PY  - 2009///
CY  - London
PB  - Henry Stewart Talks
KW  - Arthritis, Rheumatoid
KW  - drug therapy
KW  - Immunity, Innate
KW  - Tumor Necrosis Factor-alpha
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: What are cytokines? -- Early experiments -- Human cytokines in the 1980s -- Identification of TNFalfa at protein and genomic level -- TNFalfa and anti- TNFalfa antibodies -- Rheumatoid arthritis (RA): burden of disease -- Pathology of RA -- IL-1 and TNFalfa -- Cytokine cascade in RA -- A molecular hypothesis -- First anti-TNF (cA2/infliximab) in clinical trials in RA -- How does anti-TNF work? -- Why is cellularity reduced? -- Anti-TNF therapy inhibits cartilage and especially bone destruction -- Infliximab regulates altered T and B cell immunity -- Biological effects of Infliximab -- Anti-TNF biologicals in the lab -- Efficacy in randomized clinical trials -- Effective anti-TNF therapy demonstrates shared TNF-pathways in other diseases -- Adverse events and safety issues -- Limitations of anti-TNF therapy -- After TNF: what are we looking for?; Access restricted to subscribers
UR  - https://hstalks.com/bs/1314/
UR  - https://hstalks.com/bs/p/437/
ER  -