TY - BOOK AU - Turner,J.Rick AU - Durham,Todd A. ED - ebrary, Inc. TI - Integrated cardiac safety: assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance AV - RC677 .T87 2009eb U1 - 616.1/23061 22 PY - 2009/// CY - Hoboken, N.J. PB - John Wiley & Sons KW - Cardiovascular toxicology KW - Heart KW - Effect of drugs on KW - Drugs KW - Side effects KW - Testing KW - Safety measures KW - Electronic books KW - local N1 - Includes bibliographical references (p. 397-455) and index; The importance of cardiac safety assessments -- The biological basis of adverse drug reactions -- Cardiac structure and function -- Cardiac pathophysiology and disease -- Drug discovery and drug design -- Nonclinical development -- The thorough QT/QTc trial -- General safety assessments -- Therapeutic use trials and meta-analyses -- Assessment methodologies in nonexperimental postmarketing surveillance -- Postmarketing proarrhythmic cardiac safety assessments -- Generalized cardiac safety -- Medication errors, adherence, and concordance -- Future directions in drug safety; Electronic reproduction; Palo Alto, Calif.; ebrary; 2013; Available via World Wide Web; Access may be limited to ebrary affiliated libraries UR - http://site.ebrary.com/lib/daystar/Doc?id=10275622 ER -