Physiologically-based pharmacokinetic (PBPK) modeling and simulations [electronic resource] : principles, methods, and applications in the pharmaceutical industry / Sheila Annie Peters.

Includes bibliographical references and index.

Modelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain.

Electronic reproduction. Palo Alto, Calif. : ebrary, 2011. Available via World Wide Web. Access may be limited to ebrary affiliated libraries.