000			02097nam a2200349 a 4500
001			0000148430
005			20171002062140.0
006			m u
007			cr cn|||||||||
008			110510s2011 njua sb 001 0 eng d
010			_z 2011019939
020			_z9780470484067 (cloth)
020			_z9781118140383 (e-book)
035			_a(CaPaEBR)ebr10558150
035			_a(OCoLC)794619804
040			_aCaPaEBR _cCaPaEBR
050	1	4	_aRM301.5 _b.P48 2011eb
082	0	4	_a615/.7 _223
100	1		_aPeters, Sheila Annie.
245	1	0	_aPhysiologically-based pharmacokinetic (PBPK) modeling and simulations _h[electronic resource] : _bprinciples, methods, and applications in the pharmaceutical industry / _cSheila Annie Peters.
260			_aHoboken, N.J. : _bWiley, _cc2011.
300			_axvii, 430 p. : _bill.
504			_aIncludes bibliographical references and index.
505	0		_aModelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain.
533			_aElectronic reproduction. _bPalo Alto, Calif. : _cebrary, _d2011. _nAvailable via World Wide Web. _nAccess may be limited to ebrary affiliated libraries.
650		0	_aPharmacokinetics _xMathematical models.
650		0	_aDrugs _xDesign _xMathematical models.
655		7	_aElectronic books. _2local
710	2		_aebrary, Inc.
856	4	0	_uhttp://site.ebrary.com/lib/daystar/Doc?id=10558150 _zAn electronic book accessible through the World Wide Web; click to view
908			_a170314
942	0	0	_cEB
999			_c137579 _d137579