000 04434nam a22005535i 4500
001 978-3-319-16104-4
003 DE-He213
005 20180131132528.0
007 cr nn 008mamaa
008 150429s2015 gw | s |||| 0|eng d
020 _a9783319161044
_9978-3-319-16104-4
024 7 _a10.1007/978-3-319-16104-4
_2doi
050 4 _aZ5185.F66
072 7 _aPSG
_2bicssc
072 7 _aSCI045000
_2bisacsh
082 0 4 _a664.001579
_223
245 1 4 _aThe Impact of Food Bioactives on Health
_h[electronic resource] :
_bin vitro and ex vivo models /
_cedited by Kitty Verhoeckx, Paul Cotter, Iván López-Expósito, Charlotte Kleiveland, Tor Lea, Alan Mackie, Teresa Requena, Dominika Swiatecka, Harry Wichers.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aXVII, 338 p. 57 illus., 35 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- Gastrointestinal digestion models, general introduction -- Static digestion models general introduction -- InfoGest consensus method -- Approaches to static digestion models -- Dynamic digestion models general introduction -- The TNO gastro-Intestinal Model (TIM) -- Dynamic Gastric Model (DGM) -- Human Gastric Simulator (Riddet model) -- The DIDGI® System -- General introduction to cells, cell lines and cell culture -- Epithelial cell models; General introduction -- Caco-2 cell line -- HT29 cell line -- The IPEC-J2 cell line -- Co-cultivation of Caco-2 and HT-29MT -- Innate and adaptive immune cells; General introduction -- THP-1 and U937 cells -- Peripheral blood mononuclear cells -- PBMC-derived T cells -- Dendritic Cells -- Co-culture Caco-2/ immune cells -- Enteroendocrine Cell Models: General introduction -- STC-1 cells -- NCI-H716 cells -- Murine GLUTag cells -- In vitro intestinal tissue models: General introduction -- Intestinal crypt organoids as experimental models -- Porcine ex vivo intestinal segment model -- Ussing chamber -- In vitro fermentation models: General Introduction -- One compartment fermentation model -- The TNO in vitro model of the colon - TIM-2 -- The Simulator of the Human Intestinal Microbial Ecosystem – SHIME® -- The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI.
506 0 _aOpen Access
520 _aThis book describes in vitro and ex vivo models that can be employed to investigate effects of digested food products on the GIT, or specific components thereof. Many such models exist and include, for example, those used to study digestion and fermentation in the small and large intestine, to investigate absorption (e.g. Ussing chamber, epithelial cell systems), and to research the immune and enteroendocrine responses (e.g. macrophages, dendritic cells, co-cultures). In each case, these respective assays and models are discussed, and tips and tricks concerning their proper use are given. The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest. The book highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated, and highlights the strengths and weaknesses of the various assays. It is also an important resource for under-graduate students in the ‘food and health’ arena.
650 0 _aLife sciences.
650 0 _aHuman physiology.
650 0 _aFood
_xBiotechnology.
650 0 _aMicrobiology.
650 1 4 _aLife Sciences.
650 2 4 _aFood Microbiology.
650 2 4 _aFood Science.
650 2 4 _aHuman Physiology.
700 1 _aVerhoeckx, Kitty.
_eeditor.
700 1 _aCotter, Paul.
_eeditor.
700 1 _aLópez-Expósito, Iván.
_eeditor.
700 1 _aKleiveland, Charlotte.
_eeditor.
700 1 _aLea, Tor.
_eeditor.
700 1 _aMackie, Alan.
_eeditor.
700 1 _aRequena, Teresa.
_eeditor.
700 1 _aSwiatecka, Dominika.
_eeditor.
700 1 _aWichers, Harry.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319157917
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-16104-4
912 _aZDB-2-SBL
999 _c188858
_d188858