The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui
Moore, Peter, 1939-
The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui [electronic resource] / Peter Moore. - London : Henry Stewart Talks, 2008. - 1 online resource (1 streaming video file (49 min.) : color, sound). - Mechanisms of ribosome function : insights into protein synthesis, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Introduction to a paradox: how can a universally conserved cellular component be a target for pharmacologically useful antibiotics? -- Introduction to ribosome structure -- Antibiotic binding sites cluster in the ribosome -- The source of the species specificity of antibiotics that interact with the A-site cleft -- How macrolides interact with the ribosome -- The structural consequences of mutations that make ribosomes resistant to macrolides -- The toxicity of macrolides is not well understood -- 13-deoxytedanolide, a novel macrolide with novel species specificity that binds to a novel site in the ribosome.
Access restricted to subscribers.
Mode of access: World Wide Web.
1550 Henry Stewart Talks
Haloarcula Marismortui--drug effects.
Protein Biosynthesis.
Ribosomal Proteins.
Ribosomes.
The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui [electronic resource] / Peter Moore. - London : Henry Stewart Talks, 2008. - 1 online resource (1 streaming video file (49 min.) : color, sound). - Mechanisms of ribosome function : insights into protein synthesis, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Introduction to a paradox: how can a universally conserved cellular component be a target for pharmacologically useful antibiotics? -- Introduction to ribosome structure -- Antibiotic binding sites cluster in the ribosome -- The source of the species specificity of antibiotics that interact with the A-site cleft -- How macrolides interact with the ribosome -- The structural consequences of mutations that make ribosomes resistant to macrolides -- The toxicity of macrolides is not well understood -- 13-deoxytedanolide, a novel macrolide with novel species specificity that binds to a novel site in the ribosome.
Access restricted to subscribers.
Mode of access: World Wide Web.
1550 Henry Stewart Talks
Haloarcula Marismortui--drug effects.
Protein Biosynthesis.
Ribosomal Proteins.
Ribosomes.