The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui [electronic resource] / Peter Moore.
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Animated audio-visual presentation with synchronized narration.
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Contents: Introduction to a paradox: how can a universally conserved cellular component be a target for pharmacologically useful antibiotics? -- Introduction to ribosome structure -- Antibiotic binding sites cluster in the ribosome -- The source of the species specificity of antibiotics that interact with the A-site cleft -- How macrolides interact with the ribosome -- The structural consequences of mutations that make ribosomes resistant to macrolides -- The toxicity of macrolides is not well understood -- 13-deoxytedanolide, a novel macrolide with novel species specificity that binds to a novel site in the ribosome.
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